Accepted at 11:54 p.m. Oct, 31, 2023 by dollajas
Author: alexanderchang1
Related Note: 1487116826422 2
Rationale for change

UWorld question 17446 tests this specific distinction, indicating it is important and also inadequately covered by the current two clozes.


Source regarding MHCII Extra note in addition to UWorld.
https://www.nature.com/articles/nri3818/figures/1

Text Text
Extra
- TAP = transporter associated with antigen processing

- Endogenous antigens are tagged by ubiquitin ligases for proteasomal degradation, then the cytosolic peptides are taken into the rough ER via the TAP whereupon they are loaded into nascent MHC I molecules


Photo credit: Scray, CC BY-SA 3.0, via Wikimedia Commons
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