Rejected
at 4:41 p.m. Dec, 20, 2023 ]
by
Cameron
Author:
oneMedGuy
Type of change:
Updated content
Rationale for change
Not really sure why the others weren't mentioned
They're quite important to mention as they play an important role in both pathogensis & diagnosis
https://next.amboss.com/us/article/YS0ny2?q=celiac#lv0vZR
Rejection reason
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Lecture Notes
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Missed Questions
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Pathoma
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Boards and Beyond
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First Aid
Sketchy
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Sketchy 2
Watch Celiac Disease and Malabsorption
Watch Celiac Disease and Malabsorption
Sketchy Extra
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Picmonic
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Pixorize
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Physeo
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OME
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Additional Resources
Atlas:
Celiac disease etiopathogenesis
In patients with celiac disease, ingestion of gliadin, a component of gluten, leads to an immune response in the intestinal epithelium. Gliadin is deaminated by tissue transglutaminase (tTG) and then ingested by antigen-presenting cells (APC), which activate T cells via MHC II receptors. The activated T cell then activates plasma cells to release anti-tTG, antiendomysial, and antideaminated gliadin antibodies (which all function as diagnostic markers of celiac disease). T cells also differentiate into TH1 cells, which activate cytoplasmic fibroblasts to release matrix proteases. This leads to the destruction of the intestinal architecture with villus atrophy, crypt hyperplasia, and the loss of the brush border.
Atlas:
One by one
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