Accepted at 11:57 p.m. Dec, 13, 2023 by Cameron
Author: bri012
Related Note: 1473385363577
Rationale for change

HIF1a is a transcription factor that does not leave the cell, thus it is more appropriate to say that it acts "in" renal fibroblasts instead of "on" them.

This topic isn't covered by FA or Robbins, Costanzo is where the error originated from, and I don't have access to UWorld or Amboss, so the best source I can offer is this highly cited review paper on the topic authored by the current chair of nephrology at Vanderbilt: PMID 16554418 (see second sentence of abstract). Thanks as always!

Text Text
Extra
Hypoxia → ↑ hypoxia-inducible factor 1α → ↑ EPO mRNA → ↑ EPO synthesis → ↑ proerythroblasts → ↑ erythrocytes

- pVHL is an E3 ubiquitination ligase that regulates HIF1α (hypoxia-inducible factor 1α) under conditions of normoxia, marking it for degradation by proteasome

- HIF1α is a transcription factor involved in the promotion of angiogenesis
- In hypoxia, HIF1α can dimerize with HIF1β to activate transcription of VEGF, PDGF, EPO (resulting in formation of new vasculature and RBCs)


Photo credit: Simon Caulton, CC BY-SA 3.0, via Wikimedia Commons
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