Embeded Suggestion

Accepted at: Nov, 01, 2023 4:36 a.m.

Author: Ahmed7

Accepted at 4:36 a.m. on Nov. 1, 2023 by Ahmed7

Related Deck: 1659122273009

Accepted

Rationale for new note

mnemonic card #1

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The signs/symptoms of multiple myeloma may be remembered with the mnemonic {{c1::CRAB}}

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The <u>signs/symptoms</u> of <b>multiple myeloma</b> may be remembered with the mnemonic {{c1::<b>CRAB</b>}}

Extra

hyperCalcemia
Renal insufficiency
Anemia*
Bone lytic lesions / Back pain

*The anemia may be due to decreased bone marrow AND/OR decreased EPO from renal failure

CRAB Criteria

Calcium (hypercalcemia)
> 11 mg/dL or > 1 mg/dL above the ULN

Renal insufficiency:
GFR < 40 mL/min or serum creatinine > 2 mg/dL

Anemia:
Hb < 10 g/dL or more than 2 g/dL below the LLN

Bone lesions:
≥ 1 osteolytic lesions on imaging

Extra

hyper<u><b>C</b></u>alcemia<br><b><u>R</u></b>enal insufficiency<br><b><u>A</u></b>nemia*<br><b><u>B</u></b>one lytic lesions / <b><u>B</u></b>ack pain<br><br>*The anemia may be due to decreased bone marrow AND/OR decreased EPO from renal failure<br><br><b></b><table border="1" style="border-collapse: collapse;"><tbody><tr><td style="text-align: center;"><span style="text-decoration-line: underline;">CRAB Criteria</span></td></tr><tr><td><b><span style="text-decoration-line: underline;">C</span>alcium</b> (hypercalcemia)<br>> 11 mg/dL or > 1 mg/dL above the ULN</td></tr><tr><td><b><span style="text-decoration-line: underline;">R</span>enal insufficiency</b>:<br>GFR < 40 mL/min or serum creatinine > 2 mg/dL</td></tr><tr><td><b><span style="text-decoration-line: underline;">A</span>nemia</b>:<br>Hb < 10 g/dL or more than 2 g/dL below the LLN</td></tr><tr><td><b><span style="text-decoration-line: underline;">B</span>one lesions</b>:<br>≥ 1 osteolytic lesions on imaging</td></tr></tbody></table>

Lecture Notes

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Lecture Notes

Missed Questions

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Missed Questions

Pathoma

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Pathoma

Boards and Beyond

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Boards and Beyond

First Aid

Sketchy

Watch Plasma Cell Neoplasms

Sketchy

<br><img src="Screen Shot 2020-02-26 at 7.41.57 AM_1566160514431.JPG"><img src="Zoverall picture (85)_1566160514431.JPG"><img src="MM normochromic normocytic anemia_1566160514431.jpg"><img src="MM hypercalcemia_1566160514431.jpg"><img src="MM height reduction and back apin_1566160514431.jpg"><img src="MM renal failure due to Bence_1566160514431.jpg"><img src="MM renal injury_1566160514431.jpg"><br><br><a href="https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-myeloid-lymphoid/videos/medical-pathophysiology-myeloid-and-lymphoid-lymphoid-and-plasma-cell-disorders-plasma-cell-neoplasms?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical">Watch Plasma Cell Neoplasms</a>

Sketchy 2

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Sketchy 2

Sketchy Extra

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Sketchy Extra

Picmonic

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Picmonic

Pixorize

Physeo

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Physeo

Bootcamp

Watch associated Bootcamp video

Bootcamp

<a href="https://app.bootcamp.com/med-school/hematology-and-oncology/videos/plasma-cell-dyscrasias-and-myeloproliferative-disease?index=2">Watch associated Bootcamp video</a>

OME

Additional Resources

Atlas:

Other:

1) Hypercalcemia/bone lytic lesions/back pain: suck out ca from bone
2) Renal: excess light chain exceeds reabsorption ability of kidney, so light chains deposit in tissue and also cause light chains in the urine (Bence Jones; detected with SPEP); also, hypercalcemia damages kidney's ability to concentrate urine
3) Anemia: replacement of bone marrow with plasma cells, so less RBCs produced. Also renal failure leads to low EPO production

Additional Resources

<b>Atlas:</b><br><img class="resizer" src="tmp9p9BAZ.png"><br><b>Other:</b><br><img class="resizer" src="tmpYAZhT6.png"><br><div><div><i><div><div style="font-style: normal;"><b>1) Hypercalcemia/bone lytic lesions/back pain</b>:<b> </b>suck out ca from bone</div><div style="font-style: normal;"><b>2) Renal</b>:<b> </b>excess light chain exceeds reabsorption ability of kidney, so light chains<b> deposit in tissue </b>and also cause light chains in the urine (Bence Jones; detected with SPEP); also, <b>hypercalcemia</b> <b>damages</b> kidney's ability to concentrate urine</div><div style="font-style: normal;"><b>3) Anemia</b>: replacement of bone marrow with plasma cells, so less RBCs produced. Also renal failure leads to low EPO production</div></div><br></i></div><div><i><img class="resizer" src="paste-4868500048838657.jpg"></i></div></div><div><b><i><img class="resizer" src="paste-1758149157584897.jpg"></i></b><br></div><div><i><div style="font-weight: 800;"><img class="resizer" src="paste-6142516197851139.jpg"></div></i></div>

One by one

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One by one

Tags

!AK_UpdateTags::Step1decks::Zanki-Step-Decks::Zanki-Hematology-&-Oncology::Pathoma-WBC !AK_UpdateTags::Step2decks::Cheesy-Dorian-(M3)::xStep-2-NBME-and-Self-Assessments::SAs #AK_Original_Decks::Step_1::Zanki_Step_Decks::Zanki_Hematology_&_Oncology::Pathoma_WBC #AK_Original_Decks::Step_2::Cheesy_Dorian_(M3) #AK_Step1_v12::#AMBOSS::HematOnco #AK_Step1_v12::#B&B::11_Hematology::03_WBC::05_Plasma_Cell_Disorders #AK_Step1_v12::#Bootcamp::Hematology_and_Oncology::10_Plasma_Cell_Dyscrasias_&_Myeloproliferative_Disease::01_Multiple_Myeloma #AK_Step1_v12::#FirstAid::10_Hematology_Oncology::04_Pathology::26_Plasma_Cell_Dyscrasias #AK_Step1_v12::#FirstAid::10_Hematology_Oncology::04_Pathology::26_Plasma_Cell_Dyscrasias::Multiple_Myeloma #AK_Step1_v12::#OME::13_Hematology_Oncology::04_Proliferation::05_Plasma_Cell_Dyscrasis #AK_Step1_v12::#OME_banner::Clinical::05_Hematology_Oncology::07_Plasma_Cell #AK_Step1_v12::#Pathoma::06_WBC::08_Plasma_Cell_(Dyscrasias) #AK_Step1_v12::#Physeo::11_Pathology::10_HemeOnc_Pathology::18_Plasma_Cell_Dyscrasias #AK_Step1_v12::#Pixorize::01_Biochemistry::19_Plasma_Cell_Dyscrasias::02_Multiple_Myeloma #AK_Step1_v12::#SketchyPath::10_Myeloid_&_Lymphoid::02_Lymphoid_&_Plasma_Cell_Disorders::04_Plasma_Cell_Neoplasms #AK_Step1_v12::#UWorld::1054 #AK_Step1_v12::#UWorld::12101 #AK_Step1_v12::#UWorld::15133 #AK_Step1_v12::#UWorld::15134 #AK_Step1_v12::#UWorld::25819 #AK_Step1_v12::^Other::^HighYield::1-HighYield #AK_Step1_v12::^Other::^One_by_one #AK_Step1_v12::^Systems::HemeOnc::WBC #AK_Step2_v12::!Shelf::IM::no_dupes #AK_Step2_v12::#AMBOSS::IM #AK_Step2_v12::#NBME #AK_Step2_v12::#OME::05_Heme_Onc::07_Plasma_Cell #AK_Step2_v12::#OME_banner #AK_Step2_v12::#Resources_by_rotation::FM::examguru #AK_Step2_v12::#Resources_by_rotation::IM::emma #AK_Step2_v12::#Resources_by_rotation::IM::ome::heme/onc::plasma_cell #AK_Step2_v12::#Resources_by_rotation::IM::uw::#misc_zanki #AK_Step2_v12::#Resources_by_rotation::IM::uw::heme/onc::heme/onc_dorian #AK_Step2_v12::#Resources_by_rotation::IM::uw::heme/onc::heme/onc_zanki #AK_Step2_v12::#Resources_by_rotation::tests_dorian::sa1 #AK_Step2_v12::#SketchyIM::06_Electrolytes_&_Acid_Base::03_Calcium_Abnormalities::02_Hypercalcemia_(Workup_&_Management) #AK_Step2_v12::#Subjects::Hematology::03_WBC::05_Plasma_Cell_Disorders::Multiple_Myeloma #AK_Step2_v12::#Subjects::Hematology::03_WBC::05_Plasma_Cell_Disorders::Multiple_Myeloma::Pathophysiology #AK_Step2_v12::#UWorld::17681 #AK_Step2_v12::#UWorld::2864 #AK_Step2_v12::#UWorld::2889 #AK_Step2_v12::#UWorld::4013 #AK_Step2_v12::#UWorld::4466 #AK_Step2_v12::$AnKingUpdates::$Errata::v10-minor_text_changes #AK_Step2_v12::Original_decks::Dorian::fam::exam_guru #AK_Step2_v12::Original_decks::Dorian::im::emma #AK_Step2_v12::Original_decks::Dorian::im::ome::heme/onc::plasma_cell #AK_Step2_v12::Original_decks::Dorian::im::uw::heme/onc #AK_Step2_v12::Original_decks::Dorian::step2::sa1 #AK_Step2_v12::Original_decks::Zanki_Step_2::IM::HemeOnc #AK_Step2_v12::Original_decks::Zanki_Step_2::UW