Accepted at 6:45 p.m. Oct, 31, 2023 by dollajas
Author: Ahmed7
Related Note: 1508799500223
Rationale for change

capitalized Merlin and Schwannomin

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Extra
- Merlin is involved in contact inhibition; a behavior expressed by fibroblast-like cells when they adhere to each other or come into contact

- If the cells adhere to each other, this signals each cell to stop growing outwards; when cadherins link, this leads to dephosphorylation of merlin which causes cell cycle arrest and tumor suppression (for as long as the cells are in contact; linked by cadherins)

- If mutated, fibroblast-like cells divide and grow over each other in an uncontrolled manner (important in cancer invasion / metastasis)
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#AK_Step1_v12::#OME_banner #AK_Step1_v12::#Pixorize::01_Biochemistry::05_Autosomal_Dominant_Diseases::11_Neurofibromatosis_Type_II_(NF_II) #AK_Step1_v12::#FirstAid::04_Pathology::03_Neoplasia::09_Tumor_suppressor_genes::*NF2 #AK_Step1_v12::#Pathoma::03_Neoplasia_Alt_Tagging::Lolnotacop::02_Carcinogenesis::3_Tumor_Suppressor_Genes::Tumor_Suppressor_Genes #AK_Step1_v12::#Physeo::11_Pathology::05_Neuropathology_Pathology::09_Neurocutaneous_Disorders #AK_Step1_v12::#Pixorize::^Missing_image !AK_UpdateTags::Step1decks::Lolnotacop::Etc::Pathoma-Chapter-3-(Neoplasia-upgrade) #AK_Step1_v12::#UWorld::Step::1305 #AK_Step1_v12::#UWorld::COMLEX::24416 #AK_Step1_v12::#AMBOSS::w3ahk4 #AK_Original_Decks::Step_1::Lolnotacop::Etc::Pathoma_Chapter_3_(Neoplasia_-_upgrade) #AK_Step1_v12::#SketchyPath::13_Neuro::04_Congenital_&_Neurocutaneous::03_Neurofibromatosis #AK_Step1_v12::#Physeo::11_Pathology::07_General_Pathology::09_Carcinogenesis #AK_Step1_v12::#Pathoma::03_Neoplasia::02_Carcinogenesis::3_Tumor_Suppressor_Genes::lol_extra::Tumor_Suppressor_Genes