Accepted
at 2:02 p.m. Oct, 22, 2023
by
Ahmed7
Bulk Suggestion
Bulk ID:
tmchan/10.22.23-01:55PM
Author:
tmchan
Rationale for change
UWorld #2725 covers aldosterone escape. Currently tagged notes for the question do not.
No changes in fields
Text
Primary hyperaldosteronism activates "aldosterone escape", which leads to a steady state of {{c1::normonatremia::sodium levels}}, {{c1::hypokalemia::potassium levels}} and {{c1::hypervolemia::volume levels}}
Extra
- Excess aldosterone → increased Na+ reabsorption → negative luminal charge, which pulls K+ and H+ into urine → hypokalemia + metabolic alkalosis
- Despite the increase in Na+ reabsorption, hypernatremia and pedal edema are rarely observed due to increased intravascular volume, which increases renal blood flow (resulting in pressure natriuresis and normal sodium levels)
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