Accepted at 9:37 p.m. Oct, 10, 2023 by Cameron
Author: NikaVashakidze
Co-authors: Ahmed7 , Cameron
Related Note: 1508366937063
Rationale for change

"Trimethoprim-sulfamethoxazole is safe in the second trimester but contraindicated in the first because it interferes with folic acid metabolism, which is critical to early fetal development. It is also contraindicated in the third trimester (!!!) due to the risk for neonatal kernicterus"
Source: UWorld - Step 2 4472

Extra Extra
Text
TMP-SMX is contraindicated in the {{c2::1st}} trimester (pregnancy), due to its effects on folate metabolism
Lecture Notes
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Pathoma
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Boards and Beyond
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First Aid
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Watch Trimethoprim/Sulfamethoxazole
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Bootcamp
Watch associated Bootcamp video - Antibiotics: Diaminopyrimidines and Sulfonamides

Watch associated Bootcamp video - DNA Structure : Clinical Applications of the Pyrimidine Pathway

Watch associated Bootcamp video - Macrocytic Anemia: Folate (Vitamin B9) Deficiency
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#AK_Step1_v12::#OME_banner #AK_Step1_v12::#FirstAid::03_Microbiology::07_Antimicrobials::20_Sulfonamides #AK_Step2_v12::#SketchyOBGYN::01_Prenatal_Care_&_Early_Pregnancy::02_Prenatal_Care::01_Early_Pregnancy_&_Prenatal_Care #AK_Step1_v12::#Bootcamp::Microbiology::36_Antibiotics::19_Diaminopyrimidines_and_Sulfonamides #AK_Step1_v12::#SketchyPharm::07_Antimicrobials::04_Other_Antibiotics::01_Trimethoprim/Sulfamethoxazole #AK_Step1_v12::#Bootcamp::Genetics::01_DNA_Structure::05_Clinical_Applications_of_the_Pyrimidine_Pathway #AK_Step1_v12::#Physeo::09_Pharm::05_Antibiotics::18_Trimethoprim_&_Sulfonamides #AK_Step2_v12::#SketchyFM::01_Acute_Presentations::08_Obstetrics_&_Gynecology::01_Early_Pregnancy_&_Prenatal_Care #AK_Step1_v12::#Bootcamp::Hematology_and_Oncology::05_Macrocytic_Anemia::01_Folate_(Vitamin_B9)_Deficiency #AK_Original_Decks::Step_1::Lolnotacop::Drugs !AK_UpdateTags::Step1decks::Lolnotacop::Drugs #AK_Step1_v12::#B&B::20_Repro::01_Embryology::05_Teratogens_I #AK_Step2_v12::#UWorld::COMLEX::101258 #AK_Step1_v12::#Physeo::^physeo_image_update #AK_Step2_v12::#UWorld::Step::4472 #AK_Step2_v12::#B&B::11_Obstetrics_and_Gynecology::01_Obstetrics::05_Teratogens #AK_Step1_v12::#FirstAid::03_Microbiology::07_Antimicrobials::53_Antimicrobials_to_avoid_in_pregnancy