Rejected at 1:20 a.m. Oct, 09, 2023 ] by Cameron
Author: kaleandr
Related Note: 1475704810517
Rationale for change

Idk why "multiple" is outside the cloze. That is way too big of a hint. If I see that I know right away its multiple myeloma. Put it inside the cloze for better memory retention. We need to remember "multiple myeloma", not "myeloma."

Rejection reason

Going to leave as is for now (see comments), if you can come up with a good hint please resubmit

Text Text
Extra
Only Fanconi syndrome causes an increased risk for hypophosphatemic rickets (but multiple myeloma can lead to Fanconi syndrome)

Renal tubular acidosis
Type 1 (distal) Type 2 (proximal) Type 3 (mixed) Type 4 (collecting duct)
Primary defect ↓ H+ secretion into urine ↓ Bicarbonate reabsorption Combination of distal and proximal RTA ↓ Aldosterone (deficiency or resistance)
↓ NH4 excretion
Urine pH ≥ 5.5 < 5.5 > 5.5 < 5.5
Associations Associated with kidney stones Associated with Fanconi Associated with osteopetrosis, cerebral calcification, mental retardation Associated with diabetic nephropathy
Electrolytes
[all types - metabolic acidosis with normal serum anion gap]		 Hypokalemia (low or low-normal); positive urine AG Hypokalemia (low or low-normal); negative urine AG Hypokalemia; positive urine AG Hyperkalemia; positive urine AG
Cause Medication toxicity (amphotericin, ifosfamide, lithium, NSAIDs)
Autoimmune disorders
Genetic disorders		 Genetic disorder
Fanconi syndrome 		Carbonic anhydrase II deficiency (autosomal recessive) Congenital adrenal hyperplasia
Obstructive uropathy
Uncontrolled DM
Addison's disease
Drugs (ACE inhibitors, ARBs)
Treatment Sodium bicarbonate, sodium citrate Potassium citrate Sodium citrate, potassium citrate Furosemide + fludrocortisone
Lecture Notes
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Missed Questions
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Pathoma
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Boards and Beyond
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First Aid


Sketchy


Watch Renal Tubular Acidosis (RTA)



Watch Plasma Cell Neoplasms
Sketchy 2
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Sketchy Extra
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Picmonic
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Pixorize


Review Multiple Myeloma
Physeo
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Bootcamp
Watch associated Bootcamp video - Type 2 RTA
OME

Additional Resources
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#AK_Step1_v12::#OME::Clinical::Internal_Medicine::Hematology-Oncology::Plasma_Cell_Dyscrasias #AK_Step1_v12::^Other::^FA_Updates::FA2018 !AK_UpdateTags::Step1decks::Zanki-Step-Decks::Zanki-Renal::Renal-Physiology+Embryo,Anatomy #AK_Step1_v12::#Physeo::11_Pathology::10_HemeOnc_Pathology::18_Plasma_Cell_Dyscrasias #AK_Step1_v12::^Other::^EXPN::BGedit #AK_Step1_v12::^Other::^HighYield::2-RelativelyHighYield !AK_UpdateTags::Table::Renal_Tubular_Acidosis #AK_Step1_v12::#FirstAid::14_Renal::03_Physiology::12_Renal_tubular_defects::*Fanconi_Syndrome #AK_Step1_v12::#Bootcamp::Nephrology::06_Acid-Base_Physiology::08_Type_2_RTA #AK_Step1_v12::#SketchyPath::10_Myeloid_&_Lymphoid::02_Lymphoid_&_Plasma_Cell_Disorders::04_Plasma_Cell_Neoplasms #AK_Step1_v12::#Pixorize::01_Biochemistry::19_Plasma_Cell_Dyscrasias::02_Multiple_Myeloma #AK_Step1_v12::^Other::^FA_Updates::FArenal #AK_Step1_v12::^Systems::Renal::Physiology #AK_Step1_v12::#B&B::19_Renal::02_Acid-Base::05_Renal_Tubular_Acidosis #AK_Step1_v12::#UWorld::Step::7626 #AK_Step2_v12::#B&B::15_Renal_and_Genitourinary::03_Acid_Base::05_Renal_Tubular_Acidosis #AK_Step1_v12::#UWorld::COMLEX::25324 #AK_Step1_v12::#SketchyPath::04_Renal::06_Volume,_Electrolyte_&_Acid/base_Disorders::05_Renal_Tubular_Acidosis_(RTA) #AK_Step1_v12::#FirstAid::10_Hematology_and_Oncology::04_Pathology::26_Plasma_cell_dyscrasias #AK_Step1_v12::#FirstAid::14_Renal::03_Physiology::23_Renal_tubular_acidosis::*Type_2_Proximal #AK_Original_Decks::Step_1::Zanki_Step_Decks::Zanki_Renal::Renal_Physiology_+_Embryo,_Anatomy