Accepted
at 4:24 a.m. Nov, 01, 2023
by
jaynguyen
Author:
jaynguyen
Type of change:
Content error
Rationale for change
Minor rewording, because I don't think GNAQ/GNA11 mutation alone has a high risk of metastasis but it's the combination of both GNAQ/GNA11 mutation AND BAP1 loss that portends a high risk of mets
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Personal Notes
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Dermoscopy
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VisualDx
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Melanoma Subtypes (DermatoGraphix)
Superficial Spreading Melanoma
•Superficial raft: Superficial spreading melanoma
•Floats horizontally on the water = long horizontal growth phase
•Shirtless man: Predilection for trunk in men
•Woman with legs hanging off raft: Predilection for legs in women
Nodular Melanoma
•Nodular Rocket launch: Nodular melanoma
•Astronaut helmet on head/neck: Most commonly on head/neck
•Helmet is blue/black: Rapidly growing blue/black nodule
•Man: Males > females
•Rocket launches vertically: Lacks horizontal growth phase
Lentigo Maligna
•Dark algae floating in tank: Lentigo maligna
•Algae grows with sunlight: Affects chronically sun-damaged sites, particularly head and neck
•Irregularly shaped, dark algae: Presents as an irregularly pigmented brown macule/patch
•Floating on the water: Long horizontal growth phase
Acral Lentiginous Melanoma
•Bob Marley with a dark spot on his palm: Acral lentiginous melanoma (the same melanoma that took his life)
•Dark skinned: Most common type seen in darkly pigmented races
•Black nail + “Hutch” shirt: Nail matrix lesions appear as longitudinal melanonychia with Hutchinson sign (involvement of lateral or proximal nail folds)
Desmoplastic Melanoma
•Disco: Desmoplastic melanoma
•$100 bill: S100 positive
•Funky sox: SOX-10 positive
•Melon with “A” on it broken on floor: Melan-A negative
•Dead hummingbird: HMB45 negative
•Melon seed stuck on the roof of mouth: Mucosal melanoma most commonly affects hard palate
•Holding a stopwatch: Most important prognostic factor is early diagnosis as 50% metastasize
Spitzoid Melanoma+
•Spitting out watermelon seed: Spitzoid melanoma
•Having a pina colada with 9-shaped straw + just turned 21: Homozygous loss of 9p21
•FISH: Detected by FISH
•Sad fish thrown overboard: Associated with a poor outcome
Uveal Melanoma
•GINA with a GNAQ (“G-nack”) snack: GNAQ/GNA11 mutations
•Eyedrops: Uveal melanoma
•Bat: Very high risk of metastasis if concomitant BAP-1 loss
•Blue crab: associated with malignant blue nevus
DermNet
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Full Spectrum of Dermatology
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