Accepted at 9:37 p.m. Oct, 31, 2023 by Joe
Author: iolknjlk
Related Note: 1476583696264 1
Rationale for change

It's fixed in First Aid 2022 from Sulfonamides to Trimethoprim because Trimethoprim inhibits Dihydrofolate Reductase while Sulfonamides inhibits prokaryotic Folate synthesis only not eukaryotic

Text Text
Extra
- Folate is obtained from green veggies and some fruits and absorbed in the jejunum

Causes of folate deficiency:
- Malnutrition / poor diet: often seen in alcohol use disorder (most common nutritional cause of folate deficiency in the US) and the elderly
- Malabsorption
- Hemolytic anemia (increased requirement)
Lecture Notes
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Missed Questions
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Pathoma
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Boards and Beyond
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First Aid
Sketchy
Watch Megaloblastic Anemia: Folate Deficiency & Vitamin B Deficiency


Watch Vitamin B9 (Folate)
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Watch Macrocytic Anemia DDx





Watch OB Early Pregnancy & Prenatal Care
Watch FM Early Pregnancy & Prenatal Care
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Picmonic
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Pixorize

Review Vitamin B9 and B12 Deficiencies

Review De Novo Pyrimidine Synthesis
Physeo






Bootcamp
Watch associated Bootcamp video - Physiology: Vitamins

Watch associated Bootcamp video - Macrocytic Anemia: Folate (Vitamin B9) Deficiency

Watch associated Bootcamp video - Vitamins: Vitamin B9 (Folate)
OME

Additional Resources
MMA levels in B12 deficiency are high
One by one
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#AK_Step1_v12::#FirstAid::01_Biochem::05_Nutrition::12_Vitamin_B9::01_Function #AK_Step1_v12::^Other::^HighYield::1-HighYield #AK_Step2_v12::#Resources_by_rotation::IM::uw::gi_nutrition::gi_nutrition_dorian #AK_Step2_v12::Original_decks::Dorian::im::uw::gi #AK_Step1_v12::#FirstAid::01_Biochem::05_Nutrition::12_Vitamin_B9 #AK_Step1_v12::#Bootcamp::Biochemistry::12_Vitamins::13_Vitamin_B9_Folate #AK_Original_Decks::Step_1::Zanki_Step_Decks::Zanki_Hematology_&_Oncology::Pathoma_RBC #AK_Step2_v12::Original_decks::Zanki_Step_2::IM::GI_&_Nutrition #AK_Step2_v12::#Resources_by_rotation::FM::casefiles::geriatric_anemia !AK_UpdateTags::Step1decks::Zanki-Step-Decks::Zanki-Biochemistry::Vitamins !AK_UpdateTags::Step1decks::Zanki-Step-Decks::Zanki-Hematology-&-Oncology::Pathoma-RBC #AK_Step2_v12::!Shelf::IM::no_dupes #AK_Step1_v12::#B&B::03_Biochem::04_Vitamins::02_B12_and_Folate::Extra #AK_Step1_v12::#Pathoma::05_RBC::03_Macrocytic_Anemia #AK_Step2_v12::#SketchyIM::08_Hematology_&_Oncology::02_Anemia::03_Macrocytic_Anemia_DDx #AK_Step1_v12::#Physeo::05_Biochem::05_Metabolism::17_Homocysteine #AK_Step2_v12::#OME::01_Medicine::05_Hematology_Oncology::02_Macrocytic_Anemia #AK_Step1_v12::^Systems::Biochem::vitamins #AK_Step2_v12::#UWorld::Step::3930 #AK_Step1_v12::#FirstAid::10_Hematology_and_Oncology::04_Pathology::08_Macrocytic_anemias::*Megaloblastic_Macrocytic_Anemia::B9_Folate_Deficiency #AK_Step2_v12::Original_decks::Dorian::fam::casefiles::geriatric_anemia #AK_Step1_v12::#SketchyBiochem::04_Vitamins/Minerals::01_Water_Soluble::07_Vitamin_B9 #AK_Step2_v12::#SketchyIM::07_Rheumatology::Retired_Lessons::02_Systemic_Rheumatic_Diseases::01_Rheumatoid_Arthritis_SOAP_[OLD_VERSION] #AK_Step2_v12::#Resources_by_rotation::IM::uw::gi_nutrition::gi_nutrition_zanki #AK_Step1_v12::#OME::04_Organ_Systems::05_Hematology_Oncology::02_Anemia::06_Macrocytic_Anemia #AK_Step1_v12::#Physeo::05_Biochem::05_Metabolism::35_Folate_(B9)_-_Nutrition #AK_Step2_v12::#B&B::07_Hematology_and_Oncology::01_Red_Cells::04_Macrocytic_Anemia #AK_Step1_v12::#Pixorize::01_Biochemistry::01_Vitamins::12_Vitamins_B9_&_B12_Deficiencies #AK_Step2_v12::#SketchyOBGYN::01_Prenatal_Care_&_Early_Pregnancy::02_Prenatal_Care::01_Early_Pregnancy_&_Prenatal_Care #AK_Step2_v12::#UWorld::COMLEX::100937 #AK_Step2_v12::#UWorld::Step::3086 #AK_Step1_v12::#Physeo::09_Pharm::13_Psychiatric::05_Alcohol #AK_Step2_v12::#UWorld::COMLEX::100722 #AK_Step1_v12::#Physeo::05_Biochem::05_Metabolism::18_Purines_&_Pyrimidines #AK_Step1_v12::^Systems::HemeOnc::RBC #AK_Step1_v12::#Bootcamp::Hematology_and_Oncology::05_Macrocytic_Anemia::01_Folate_(Vitamin_B9)_Deficiency #PANCE::EOR::PEDS #AK_Step2_v12::#UWorld::Step::4147 #AK_Step1_v12::#Pixorize::01_Biochemistry::02_Biochemical_Pathways::06_De_Novo_Pyrimidine_Synthesis #AK_Step1_v12::#SketchyPath::09_Blood_&_Coagulation::02_Normocytic_&_Macrocytic_Anemias::05_Megaloblastic_Anemia:_Folate_Deficiency_&_Vitamin_B12_Deficiency #AK_Step2_v12::!Shelf::FM::no_dupes #AK_Step1_v12::#Bootcamp::Gastroenterology::04_Physiology::08_Vitamins #AK_Step2_v12::#UWorld::COMLEX::28893 #AK_Step1_v12::#OME::Clinical::04_Organ_Systems::05_Hematology_Oncology::02_Anemia::06_Macrocytic_Anemia #AK_Step2_v12::#SketchyFM::01_Acute_Presentations::08_Obstetrics_&_Gynecology::01_Early_Pregnancy_&_Prenatal_Care #PANCE::HEME::cytopenias #AK_Step1_v12::#Physeo::^physeo_image_update #AK_Original_Decks::Step_1::Zanki_Step_Decks::Zanki_Biochemistry::Vitamins #AK_Step1_v12::#Physeo::11_Pathology::10_HemeOnc_Pathology::10_Macrocytic_Anemia