Hypertonic solutions are advantageous to prevent secondary ischemic brain damage in patients with traumatic brain injury. Large volumes of these solutions can restore normovolemia without subsequently increasing the intracranial pressure (ICP). Hypertonic solutions {{c1::increase}} serum sodium and osmolarity, {{c1::increase}} cerebral perfusion pressure, {{c1::improve}} cardiovascular output, and {{c1::decrease}} brain water content and ICP.

Hypertonic solutions are advantageous to prevent secondary ischemic brain damage in patients with traumatic brain injury. Large volumes of these solutions can restore normovolemia without subsequently increasing the intracranial pressure (ICP). Hypertonic solutions {{c1::increase}} serum sodium and osmolarity, {{c1::increase}} cerebral perfusion pressure, {{c1::improve}} cardiovascular output, and {{c1::decrease}} brain water content and ICP.