Physiologic changes that take place during laparoscopic insufflation include:
- {{c1::Decreased}} lung compliance and {{c2::increased}} inspiratory pressure, due to an increase in intra-abdominal pressure and Trendelenburg position.
- {{c3::Increased}} ventilation-perfusion (V/Q) mismatch, due to atelectasis and decreased functional residual capacity (FRC).
- {{c4::Elevated}} CO2, due to insufflation and decreased lung perfusion and ventilation.

Most patients require an increase of 30% in minute ventilation to counter the increase in CO2 from insufflation. A modest increase in inspiratory pressures is needed to counter the reduced lung compliance and FRC associated with pneumoperitoneum.

Physiologic changes that take place during laparoscopic insufflation include:<br>- {{c1::Decreased}} lung compliance and {{c2::increased}} inspiratory pressure, due to an increase in intra-abdominal pressure and Trendelenburg position.<br>- {{c3::Increased}} ventilation-perfusion (V/Q) mismatch, due to atelectasis and decreased functional residual capacity (FRC).<br>- {{c4::Elevated}} CO2, due to insufflation and decreased lung perfusion and ventilation.<br><br>Most patients require an increase of 30% in minute ventilation to counter the increase in CO2 from insufflation. A modest increase in inspiratory pressures is needed to counter the reduced lung compliance and FRC associated with pneumoperitoneum.