Accepted
at 6:36 p.m. Oct, 31, 2023
by
dollajas
Author:
LizLemon
Type of change:
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- In contrast, the MDR2 gene encodes for another efflux pump that the liver uses to excrete conjugated bilirubin / kidney uses to excrete toxins (defective in Dubin-Johnson syndrome)
- This is an efflux pump normally used by gut and kidney to pump out toxins, tumors can use these to pump out chemotherapeutics
- In contrast, the MDR2 gene encodes for another efflux pump that the liver uses to excrete conjugated bilirubin / kidney uses to excrete toxins (defective in Dubin-Johnson syndrome)
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