Accepted
at 6:36 p.m. Oct, 31, 2023
by
rockroovy
Author:
learnwell
Type of change:
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Rationale for change
added some detail
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What class of receptor is the growth hormone receptor?
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What protein is predominantly responsible for growth?
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Where is IGF-1 produced?
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Differentiate growth hormone's effect on skeletal muscle and adipose tissue
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(1) Skeletal muscle: Anabolic
(2) Adipose tissue: Catabolic
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Indications (3) : Growth hormone (short stature)
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(1) Idiopathic
(2) Prader-Willi syndrome
(3) Turner syndrome
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MOA: Mecasermin
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IGF-1 analog
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What is the difference in how growth hormone and IGF-1 affect serum glucose?
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(1) Growth hormone: ↓ Insulin sensitivity
(2) IGF-1: Insulin-like properties
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What do you call it when an adult has a GH secreting tumor? A child?
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(1) Adult: Acromegaly
(2) Child: Gigantism
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What drug can be used to inhibit growth hormone secretion?
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Octreotide can be used to inhibit tumors secreting what 6 hormones?
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(1) Growth hormone
(2) VIP
(3) Serotonin
(4) Insulin
(5) Glucagon
(6) Gastrin
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Treatment (2) : Esophageal variceal bleeding
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(1) ADH
(2) Octreotide
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Adverse Effects (2) : Octreotide
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(1) GI upset
(2) Steatorrhea
(Inhibits digestive enzymes. e.g., ⇒ ↓ CCK ⇒ ↓ Bile acid ⇒ Gallstones)
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Name 2 D2 receptor agonists used to treat acromegaly
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MOA: Pegvisomant
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GH receptor antagonist
(May actually ↑ GH levels due to reduced negative feedback)
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MOA: Cabergoline
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D2 receptor agonist
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More About This Topic
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4.2 - Growth hormone, mecasermin, octreotide, pegvisomant