Rejected
at 5:56 p.m. Oct, 31, 2023 ]
by
dollajas
Author:
Andy
Type of change:
Updated Tags
Rationale for change
Changing to one-by-one
Rejection reason
not necessary
Current
Suggested
Text
Text
Missed Questions
Missed Questions
One by one
One by one
Text
Text
Missed Questions
Missed Questions
One by one
One by one
Extra
This card used to say quinine, but AMBOSS confirms quinidine is used for severe P. falciparum malaria (Sept 2023)
- Quinidine is used in the United States, quinine is used elsewhere
- Quinidine is a class 1A anti-arrhythmic drug that can target the erythrocytic stage of Plasmodium species
- Quinine works similarly to chloroquine, by inhibiting heme polymerization causing lysis of cell membranes
- Artesunate generates ROS which inhibits synthesis of proteins and nucleic acids
- If artesunate is not immediately available, begin interim oral treatment (e.g., artemether-lumefantrine, atovaquone-proguanil, quinidine, or mefloquine)
- Discontinue oral agent and administer IV artesunate as soon as it becomes available
- Quinidine is used in the United States, quinine is used elsewhere
- Quinidine is a class 1A anti-arrhythmic drug that can target the erythrocytic stage of Plasmodium species
- Quinine works similarly to chloroquine, by inhibiting heme polymerization causing lysis of cell membranes
- Artesunate generates ROS which inhibits synthesis of proteins and nucleic acids
- If artesunate is not immediately available, begin interim oral treatment (e.g., artemether-lumefantrine, atovaquone-proguanil, quinidine, or mefloquine)
- Discontinue oral agent and administer IV artesunate as soon as it becomes available
Lecture Notes
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Pathoma
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Boards and Beyond
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First Aid
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