Accepted at: Sep, 30, 2024
1:46 p.m.
Author:
Stapedius
Related Deck:
1675118865074
Accepted
Rationale for new note
multiple myeloma mneminc
Text
The clinical features of Multiple Myeloma can be remembered with the mnemonic "{{c1::CRABBI}}":
{{c1::Calcium ↑}}
{{c1::Renal impariment}}
{{c1::Anaemia}}
{{c1::Bleeding}}
{{c1::Bones}}
{{c1::Infection}}
{{c1::Calcium ↑}}
{{c1::Renal impariment}}
{{c1::Anaemia}}
{{c1::Bleeding}}
{{c1::Bones}}
{{c1::Infection}}
Text
The clinical features of <b>Multiple Myeloma </b>can be remembered with the mnemonic "{{c1::CRABBI}}":<br><br>{{c1::<u>C</u>alcium ↑}}<br>{{c1::<u>R</u>enal impariment}}<br>{{c1::<u>A</u>naemia}}<br>{{c1::<u>B</u>leeding}}<br>{{c1::<u>B</u>ones}}<br>{{c1::<u>I</u>nfection}}
Extra
- Hypercalcaemia is due primarily to increased osteoclastic bone resorption caused by local cytokines released by the myeloma cells
- The renal issues stem from monoclonal production of Igs resulting in light chain deposition within the rental tubules
- Anaemia is due to bone marrow crowding suppressing erythropoiesis
- Bleeding results in thrombocytopaenia
- Bone marrow infiltration by plasma cells creates lytic bone lesions (can present as pain especially in the back and risk of pathological fractures)
- Infection due to reduction in normal Ig production
- The renal issues stem from monoclonal production of Igs resulting in light chain deposition within the rental tubules
- Anaemia is due to bone marrow crowding suppressing erythropoiesis
- Bleeding results in thrombocytopaenia
- Bone marrow infiltration by plasma cells creates lytic bone lesions (can present as pain especially in the back and risk of pathological fractures)
- Infection due to reduction in normal Ig production
Extra
- Hypercalcaemia is due primarily to increased osteoclastic bone resorption caused by local cytokines released by the myeloma cells<br>- The renal issues stem from monoclonal production of Igs resulting in light chain deposition within the rental tubules<br>- Anaemia is due to bone marrow crowding suppressing erythropoiesis<br>- Bleeding results in thrombocytopaenia<br>- Bone marrow infiltration by plasma cells creates lytic bone lesions (can present as pain especially in the back and risk of pathological fractures)<br>- Infection due to reduction in normal Ig production
Personal Notes
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Personal Notes
Missed Questions
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Missed Questions
Oxford Handbook
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Oxford Handbook
First Aid
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First Aid
AMBOSS
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AMBOSS
eTG Complete
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eTG Complete
Talley & O'Connor
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Talley & O'Connor
Additional Resources
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Additional Resources
Source
Myeloma: features and investigation. PassMed Textbook. Accessed September 29, 2024. https://www.passmedicine.com/.
Source
Myeloma: features and investigation. PassMed Textbook. Accessed September 29, 2024. <a href="https://www.passmedicine.com/">https://www.passmedicine.com/</a>.
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Tags
#Malleus_CM::#Mnemonics
#Malleus_CM::#Subjects::Haematology::03_WBC::04_Plasma_Cell_Disorders::Multiple_Myeloma::06_Clinical_Features
#Malleus_CM::#Resources_by_Rotation::Internal_Medicine::Haematology_&_Oncology
#Malleus_CM::#Question_Banks::eMedici::0-999::194