Accepted
at 9:19 p.m. Oct, 31, 2023
by
dollajas
Author:
trablis
Type of change:
Updated content
Rationale for change
Since the 2 drugs are included in the card, it's nice to ask which 2.
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- Intensive phase: 4 drugs rifampin, isoniazid, pyrazinamide, and ethambutol for 2 months (8 weeks); this phase optimizes the killing TB and decreases risk of antibiotic resistance
- Continuation phase: 2 drugs rifampin and isoniazid for 4 months (18 weeks); this phase reduces risk of relapse
- Isoniazid is administered with pyridoxine (vitamin B6) in patients at risk for peripheral neuropathy
- Per updated 2025 ATS/CDC/ERS/IDSA guidelines, drug-susceptible pulmonary TB can now be treated in 4 months instead of 6, using 2HPZM/2HPM (isoniazid, rifapentine, pyrazinamide, moxifloxacin → isoniazid, rifapentine, moxifloxacin) in ages ≥12; whether the NBME has adopted this change remains unclear
- Continuation phase: 2 drugs rifampin and isoniazid for 4 months (18 weeks); this phase reduces risk of relapse
- Isoniazid is administered with pyridoxine (vitamin B6) in patients at risk for peripheral neuropathy
- Per updated 2025 ATS/CDC/ERS/IDSA guidelines, drug-susceptible pulmonary TB can now be treated in 4 months instead of 6, using 2HPZM/2HPM (isoniazid, rifapentine, pyrazinamide, moxifloxacin → isoniazid, rifapentine, moxifloxacin) in ages ≥12; whether the NBME has adopted this change remains unclear
Lecture Notes
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Missed Questions
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Pathoma
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Boards and Beyond
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First Aid







Sketchy




Sketchy 2
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Sketchy Extra



Watch Tuberculosis Drugs



Watch Tuberculosis Drugs
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Bootcamp
Watch associated Bootcamp video - Mycobacteria: Pulmonary Tuberculosis Diagnostics and Management
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