Created at 11:34 p.m. Jun, 17, 2026
Author:
shaunpereira
Type of change:
Content error
Rationale for change
The illustration mentions adrenal CT as next step after ARR in the diagnosis of primary hyperaldosteronism but the card clearly mentions NBS as salt loading testing. I had a question about this same concept, hence wanted to inform you
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What is the best screening test for primary hyperaldosteronism?
{{c1::Aldosterone-to-renin ratio (ARR)}}
{{c1::Aldosterone-to-renin ratio (ARR)}}
Extra
- Patients exhibit serum hypokalemia and increased urinary potassium excretion
- Aldosterone-to-renin ratio (ARR) can also be referred to as early-morning plasma aldosterone concentration (PAC) to plasma renin activity (PRA) ratio
- Typically > 20:1 ratio of PAC:PRA with a total PAC > 15 ng/dL in primary hyperaldosteronism (aldosterone made outside of normal RAAS)
- Diagnosis should be confirmed with adrenal suppression testing (e.g., aldosterone response to salt loading). The presence of high levels of aldosterone after salt loading confirms the diagnosis of hyperaldosteronism with high specificity
- Patients exhibit serum hypokalemia and increased urinary potassium excretion
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