Accepted at 10:39 p.m. Jun, 24, 2026 by braviboron
Author: kyle.robinson
Related Note: 1781130668347
Rationale for change

I believe historically the 0.18% NaCl + 4% glucose was the go to maintenance in ADULTS. Now, 0.3% NaCl + 3.3% dextrose with K+ is recommended (see guideline already in sources).

Why?
The first preparation is in practice extremely hypotonic, the glucose is rapidly taken up and metabolised by cells leaving only the 0.18% NaCl (almost free water). This is particularly problematic in unwell children who have higher levels of ADH release. It resulted in a number of deaths due to innapropriate use within that population.

The newer preparation doesn't actually fix this issue but changes it from being a severely hypotonic solution to a moderately hypotonic solution. As such it is still not indicated in unwell children.

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