Accepted
at 1:42 a.m. May, 19, 2026
by
mochigirl
Author:
mochigirl
Type of change:
Spelling/Grammar
Rationale for change
"is" describes the disease whereas "causes" implies MoA that is not there in the stem
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- Symptoms: developmental/behavioral problems, vision problems, poor coordination, adrenal insufficiency, difficulty swallowing, paraparesis
- Inheritance: X-linked, males affected
- Pathophysiology: mutation in ABCD1 gene → defective production of adrenoleukodystrophy protein (ALDP) in the membrane of peroxisomes → decreased metabolism of very long chain fatty acids (VLCFA) → accumulation of VLCFAs toxic to adrenal glands, myelin (significant accumulation in CNS, adrenals, testes)
- Symptoms: developmental/behavioral problems, vision problems, poor coordination, adrenal insufficiency, difficulty swallowing, paraparesis
Lecture Notes
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Missed Questions
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Pathoma
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Boards and Beyond
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First Aid
Sketchy
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Sketchy 2
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Sketchy Extra
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Picmonic
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Pixorize
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Review Adrenoleukodystrophy
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Review Adrenoleukodystrophy
Physeo




Bootcamp
Watch associated Bootcamp video - Cell Biology: Peroxisome
Watch associated Bootcamp video - Lipid Metabolism: Fatty Acid Degradation: β-Oxidation
Watch associated Bootcamp video - Lipid Metabolism: Fatty Acid Degradation: β-Oxidation
OME
Additional Resources


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