Accepted at 8:49 p.m. Oct, 31, 2023 by Alex
Author: jordan.phillips
Related Note: 1478915952795
Rationale for change

As pathoma explains it is more important to understand that this card is about deoxygenation (stress states) affecting cells rather than the shape of the hemoglobin (which is more of a narrow biochem Q)

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- e.g., deoxygenation, high altitude, acidosis, infection; dehydration does as well; these are conditions that favor oxygen unloading

- The taut form exposes a hydrophobic patch, causing HbS molecules to aggregate (polymerize) and form long-chain polymers

- Formation of long-chain polymers of HbS precipitates and causes sickling
Photo Credit: SpicyMilkBoy, CC BY-SA 4.0, via Wikimedia Commons


Lecture Notes
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Missed Questions
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Pathoma
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Boards and Beyond
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First Aid

Sketchy

Watch Sickle Cell Disease


Watch O2 Transport
Sketchy 2
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Sketchy Extra
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Picmonic
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Pixorize
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Physeo
Bootcamp
Watch associated Bootcamp video - Sickle Cell Anemia

Watch associated Bootcamp video - Key Mutations: Cystic Fibrosis & Sickle Cell Anemia
OME

Additional Resources
One by one
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#AK_Original_Decks::Step_1::Zanki_Step_Decks::Zanki_Hematology_&_Oncology::Pathoma_RBC #AK_Step1_v12::#FirstAid::10_Hematology_and_Oncology::04_Pathology::01_RBC_morphology::*Sickle_Cell #AK_Step1_v12::#FirstAid::10_Hematology_and_Oncology::04_Pathology::11_Intrinsic_hemolytic_anemias::*Sickle_Cell_Anemia !AK_UpdateTags::AnKing_Image::NikolausClodi AnkiHub_ImageReady::Text #AK_Step1_v12::^Other::^EXPN::Uworld #AK_Step1_v12::^Other::^EXPN::Boards&Beyond #AK_Step1_v12::#B&B::11_Hematology::02_Red_Blood_Cells::06_Sickle_Cell_Anemia #AK_Step1_v12::#Bootcamp::Hematology_and_Oncology::04_Normocytic_Anemia::03_Sickle_Cell_Anemia #AK_Step1_v12::#Physeo::^physeo_image_update #AK_Step1_v12::#OME::04_Organ_Systems::05_Hematology_Oncology::02_Anemia::07_Normocytic_Anemia #AK_Step1_v12::#OME::Clinical::04_Organ_Systems::05_Hematology_Oncology::02_Anemia::07_Normocytic_Anemia #AK_Step1_v12::#SketchyPath::09_Blood_&_Coagulation::02_Normocytic_&_Macrocytic_Anemias::04_Sickle_Cell_Disease #AK_Step1_v12::^Other::^EXPN::BGedit #AK_Step1_v12::#Bootcamp::Genetics::07_High_yield_genetic_disorders::02_Key_Mutations:_Cystic_Fibrosis_&_Sickle_Cell_Anemia #AK_Step1_v12::#UWorld::COMLEX::24352 #AK_Step2_v12::#B&B::07_Hematology_and_Oncology::01_Red_Cells::07_Sickle_Cell_Disease !AK_UpdateTags::^temporary::ImageFix::06::done #AK_Step1_v12::#UWorld::Step::1241 !AK_UpdateTags::Step1decks::Zanki-Step-Decks::Zanki-Hematology-&-Oncology::Pathoma-RBC #AK_Step1_v12::^Systems::HemeOnc::RBC #AK_Step1_v12::#Physeo::11_Pathology::10_HemeOnc_Pathology::08_Hemolytic_Anemia_Intrinsic_Causes #AK_Step2_v12::#UWorld::Step::1242 #AK_Step1_v12::#SketchyPhysiology::07_Respiratory_Physiology::03_Oxygen_Transport::01_O2_Transport #AK_Step1_v12::#Pathoma::05_RBC::05_Normocytic_Anemias_with_Extravascular_Hemolysis AnkiHub_ImageReady::Extra