Accepted
at 8:49 p.m. Oct, 31, 2023
by
Alex
Author:
jphillips767
Type of change:
Updated content
Rationale for change
As pathoma explains it is more important to understand that this card is about deoxygenation (stress states) affecting cells rather than the shape of the hemoglobin (which is more of a narrow biochem Q)
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- e.g., deoxygenation, high altitude, acidosis, infection; dehydration does as well; these are conditions that favor oxygen unloading


- The taut form exposes a hydrophobic patch, causing HbS molecules to aggregate (polymerize) and form long-chain polymers
- Formation of long-chain polymers of HbS precipitates and causes sickling

Photo Credit: SpicyMilkBoy, CC BY-SA 4.0, via Wikimedia Commons


Lecture Notes
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Missed Questions
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Pathoma
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Boards and Beyond
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First Aid


Sketchy 2
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Sketchy Extra
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Picmonic
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Pixorize
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Physeo
Bootcamp
Watch associated Bootcamp video - Normocytic Anemia: Sickle Cell Anemia
Watch associated Bootcamp video - Key Mutations: Cystic Fibrosis & Sickle Cell Anemia
Watch associated Bootcamp video - Key Mutations: Cystic Fibrosis & Sickle Cell Anemia
OME
Additional Resources
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