Accepted
at 8:10 p.m. Apr, 07, 2026
by
mmatheso
Author:
trinapphan
Type of change:
Updated content
Rationale for change
Both ALL and AML are associated with Down Syndrome. ALL has peak incidence of 2-5 years old, but can occur after 5 years. AML is mostly in older (geriatric) adults
No changes in fields
Text
{{c3::Acute lymphoblastic}} leukemia is associated with {{c1::Down}} syndrome; usually arises {{c2::after::before/after}} the age of 5 years
Extra
5YS of children with AML is worse (30%) compared to ALL (80%), though this is changing due to improvements in treatment.
"ALLder than 5 years"
5YS of children with AML is worse (30%) compared to ALL (80%), though this is changing due to improvements in treatment.
- Acute lymphoblastic leukemia (ALL) which arises after the age of 5 in Down syndrome patients
- vs acute megakaryoblastic leukemia, the most common subtype of AML in Down syndrome before the age of 5 with the associated t(1;22) translocation
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