Created at 2:10 a.m. Mar, 22, 2026
Author:
saharalruhaimi
Type of change:
Content error
Rationale for change
Bolognia: One of the principal effects of high-risk mucosal HPV E7 is to bind to the underphosphory-
lated form of RB (the retinoblastoma tumor suppressor protein). A physiologic role of underphosphorylated RB is to bind to and inhibit the function of the E2F transcription factor (see Fig. 107.4). When HPV E7 binds RB, E2F is liberated from this inhibition and is thereby able to induce the expression of genes required for DNA replication
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→ ↑ expression of genes important for DNA replication
E5, E6, and E7 genes allow viral replication above stratum basale → transcription
E5, E6, and E7 genes allow viral replication above stratum basale → transcription
Personal Notes
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Missed Questions
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DermPath
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Dermoscopy
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VisualDx
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DermNet
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Full Spectrum of Dermatology
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Dermnemonics
Boomerang (7) thrown at RootBeer bottle: E7 binds RB protein leading to loss of E2F
Dermatographix
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Textbook
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Additional Resources
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One by one
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