Created at 8:37 p.m. Mar, 07, 2026
Author: koshur
Related Note: 1475636911457 1
Rationale for change

Correction of Physiological Sequence: The current card implies that the decrease in ICP/IOP is a result of increased urine flow (diuresis). This is physiologically inaccurate.

The reduction in intracranial and intraocular pressure occurs via an osmotic gradient in the systemic vasculature, pulling free water out of the brain/eye parenchyma and into the blood before it reaches the kidney. While Mannitol does act as an osmotic diuretic in the renal tubules (increasing urine flow), the therapeutic effect on ICP/IOP is independent of—and occurs prior to—the actual production of urine.

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