Accepted at 8:32 p.m. Oct, 31, 2023 by dollajas
Author: kidCoLa
Related Note: 1478995306256
Rationale for change

Pathoma states that "IgM-mediated disease usually involves intravascular hemolysis"
While Amboss says "Cold-sensitive antibodies (cold agglutinins): mostly IgM antibodies cause extravascular hemolysis and acute intravascular hemolysis.
Intravascular hemolysis can occur, mediated through the complement system, which is activated by IgM antibodies bound to RBCs."

Due to the discrepancy between various sources (B&B and FA were cited in a previous update of the card), I think it makes the most sense that both extravascular and intravascular get included as the answer.

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#AK_Step1_v12::#Pathoma::05_RBC::06_Normocytic_Anemias_with_Intravascular_Hemolysis #AK_Other::#AK_Original_Decks::Step_1::Zanki_Step_Decks::Zanki_Hematology_&_Oncology::Pathoma_RBC #AK_Other::AnKing_Image::!Subjects::Immunology_&_Pathology::Autoimmune_hemolytic_anemia #AK_Other::AnKing_Image::AhmedA::Autoimmune_Hemolytic_Anemia #AK_Step1_v12::#B&B::12_Hematology::02_Red_Blood_Cells::02_Extrinsic_Hemolysis::Extra #AK_Step1_v12::#SketchyPath::09_Blood_&_Coagulation::02_Normocytic_&_Macrocytic_Anemias::03_G6PD_Deficiency_&_Autoimmune_Hemolytic_Anemia_(AIHA) #AK_Step1_v12::^Systems::HemeOnc::RBC #AK_Other::AnKing_Image::Mujeeb::AIHA #AK_Step1_v12::#OME::Clinical::04_Organ_Systems::05_Hematology_Oncology::02_Anemia::07_Normocytic_Anemia #AK_Step1_v12::#Bootcamp::Hematology_and_Oncology::04_Normocytic_Anemia::08_Autoimmune_Hemolytic_Anemia #AK_Step1_v12::#Bootcamp::Hematology_and_Oncology::04_Normocytic_Anemia::02_Hemolysis #AK_Step1_v12::#OME::04_Organ_Systems::05_Hematology_Oncology::02_Anemia::07_Normocytic_Anemia #AK_Step1_v12::#FirstAid::10_Hematology_and_Oncology::04_Pathology::12_Extrinsic_hemolytic_anemias::*Autoimmune_hemolytic_anemia #AK_Step1_v12::#NinjaNerd::09_Hematology::02_Pathology::22_Normocytic_Anemia_(Clinical_Medicine) #AK_Step1_v12::#Low/HighYield::3-HighYield-temporary #AK_Step2_v12::#B&B::07_Hematology_and_Oncology::01_Red_Cells::05_Extrinsic_Hemolysis::Extra #AK_Other::Only_Step_1 #PANCE::HEME::immunologic_disorders