Created at 10:59 p.m. Feb, 13, 2026
Author:
mangosteen_alibaba
Co-authors:
mitchelnelson
Type of change:
Content error
Rationale for change
the MAJOR underlying mechanism of type 2b familial dyslipidemia is increased hepatic production of apoB(100)-containing lipoproteins, not necessarily "defective LDL receptors" (that's 2a)
https://doi.org/10.1016/j.jacc.2018.05.044
https://doi.org/10.1016/j.jacc.2022.01.010
https://doi.org/10.1161/CIR.0000000000000297
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- Conversely, type IIb familial dyslipidemia is due to defective LDL receptors and increased apo B-100 synthesis

- Apo B-100 is the ligand for LDL receptor, binding results in LDL receptor uptake

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