Created at 10:04 p.m. Feb, 08, 2026
Author:
mangosteen_alibaba
Type of change:
Content error
Rationale for change
The current wording in the "Extra" field is wrong. It's not increased renal blood flow itself that causes increased Na+/water excretion (and even the original wording of "secretion" is incorrect, because Na+ and water isn't "secreted", it's merely "excreted" by being filtered and not reabsorbed), but rather the increased renal interstitial hydrostatic pressure.
This is the original wording:
- Pressure natriuresis: ↑ volume = ↑ RBF = ↑ Na+/H2O secretion
I propose this instead:
- Pressure natriuresis: ↑ volume = ↑ renal insterstitial hydrostatic pressure = ↓ Na+/H2O reabsorption → natriuresis
Sources:
https://doi.org/10.1161/01.hyp.19.1_suppl.i9
https://doi.org/10.1007/s11906-002-0040-3
No changes in fields
Text
Primary hyperaldosteronism does not directly cause edema or hypernatremia due to {{c1::aldosterone escape}}, which occurs through {{c2::pressure natriuresis}} and increased {{c2::ANP}} secretion
Extra
- Aldosterone escape mechanism/no edema and ↔ Na+: aldosterone causes retention of Na+/water, which induces ANP secretion, causing increased excretion of Na+/water

- Pressure natriuresis: ↑ volume = ↑ RBF = ↑ Na+/H2O secretion

Lecture Notes
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Pathoma
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Watch Hypernatremia



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Watch associated Bootcamp video - Hypertension: Secondary Hypertension
Watch associated Bootcamp video - Adrenal Glands : Hyperaldosteronism
Watch associated Bootcamp video - Adrenal Glands : Hyperaldosteronism
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