Accepted
at 8:23 p.m. Oct, 31, 2023
by
Joe
Author:
nicecube
Type of change:
Content error
Rationale for change
It is extravascular hemolysis not intravascular. Both 2022 first aid page 431 and boards and beyond say extravascular hemolysis for IgM immune hemolytic anemia.
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- IgG → Guarantees extravascular hemolysis
- IgM → Mostly causes extravascular hemolysis
- However, intravascular hemolysis can occur in severe cases through complement activation on RBCs bound by IgM antibodies
- IgG-mediated hemolytic anemia will cause extravascular hemolysis every time however

- IgM → Mostly causes extravascular hemolysis
- However, intravascular hemolysis can occur in severe cases through complement activation on RBCs bound by IgM antibodies
- IgG-mediated hemolytic anemia will cause extravascular hemolysis every time however

Lecture Notes
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Pathoma
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Boards and Beyond
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First Aid


Sketchy



Watch G6PD Deficiency & Autoimmune Hemolytic Anemia (AIHA)
*RBCs with IgM coating are attacked by complement → formation of MAC → hemolysis in blood vessels



Watch G6PD Deficiency & Autoimmune Hemolytic Anemia (AIHA)
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Picmonic
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Physeo
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Bootcamp
Watch associated Bootcamp video - Normocytic Anemia: Autoimmune Hemolytic Anemia
Watch associated Bootcamp video - Normocytic Anemia: Hemolysis
Watch associated Bootcamp video - Normocytic Anemia: Hemolysis
OME
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