Accepted at 8:23 p.m. Oct, 31, 2023 by Joe
Author: nicecube
Related Note: 1478995306256
Rationale for change

It is extravascular hemolysis not intravascular. Both 2022 first aid page 431 and boards and beyond say extravascular hemolysis for IgM immune hemolytic anemia.

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Extra
- IgG → Guarantees extravascular hemolysis
- IgM → Mostly causes extravascular hemolysis

- However, intravascular hemolysis can occur in severe cases through complement activation on RBCs bound by IgM antibodies

- IgG-mediated hemolytic anemia will cause extravascular hemolysis everytime however
Lecture Notes
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Missed Questions
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Pathoma
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Boards and Beyond
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First Aid

Sketchy
*RBCs with IgM coating are attacked by complement → formation of MAC → hemolysis in blood vessels


Watch G6PD Deficiency & Autoimmune Hemolytic Anemia (AIHA)
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Sketchy Extra
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Picmonic
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Pixorize
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Physeo
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Bootcamp
Watch associated Bootcamp video - Autoimmune Hemolytic Anemia
OME

Additional Resources


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