Created at 6:13 a.m. Jan, 18, 2026
Type of change:
Content error
Rationale for change
Changed "rupture" to bleeding for medical accuracy. In Heyde syndrome, the high shear stress from aortic stenosis causes the mechanical destruction (proteolysis) of von Willebrand factor (vWF) multimers. This "Acquired von Willebrand Syndrome" prevents effective platelet adhesion at the site of angiodysplasias, leading to hemorrhage rather than a mechanical rupture of the vessels.
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- Angiodysplasias are essentially AVMs of the GI tract; they are weak small vessels that are prone to bleeding
- vWF uncoils as it passes the stenotic aortic valve → vWF degraded by ADAMTS13 → intestinal angiodysplasias rupture more easily

- vWF uncoils as it passes the stenotic aortic valve → vWF degraded by ADAMTS13 → intestinal angiodysplasias rupture more easily

Photo Credit: Michael D. Dacre, CC BY-SA 4.0, via Wikimedia Commons
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