Accepted
at 12:32 a.m. Jan, 24, 2026
by
Ahmed7
Bulk Suggestion
Bulk ID:
hunterlea91/01.14.26-04:33PM
Author:
hunterlea91
Co-authors:
Ahmed7
Type of change:
New Tags
Rationale for change
NN video platelet disorders: https://youtu.be/i_c8x7TiHN0?si=sgt6pHdaCyiYjgxq
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Text
What is the next step in treating a patient with immune thrombocytopenia (ITP) and a platelet count < 30,000/µL who does not respond to corticosteroids?
{{c1::IVIG}} or {{c1::anti-Rho(D) immunoglobulin if Rh+}}
{{c1::IVIG}} or {{c1::anti-Rho(D) immunoglobulin if Rh+}}
Extra
- First-line is corticosteroids
- If there is no response to, contraindication to, or intolerance of corticosteroids: treat with IVIG or anti-Rho(D) immunoglobulin
- Anti-Rho(D) is used to intentionally overwhelm the patient's splenic macrophages (which are too preoccupied with destroying anti-Rho(D)–tagged RBCs to destroy platelets). Used very sparingly because it can cause life-threatening anemia
- If there is no response to, contraindication to, or intolerance of corticosteroids: treat with IVIG or anti-Rho(D) immunoglobulin
- Anti-Rho(D) is used to intentionally overwhelm the patient's splenic macrophages (which are too preoccupied with destroying anti-Rho(D)–tagged RBCs to destroy platelets). Used very sparingly because it can cause life-threatening anemia
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