Accepted
at 12:33 a.m. Jan, 24, 2026
by
Ahmed7
Bulk Suggestion
Bulk ID:
hunterlea91/01.14.26-04:33PM
Author:
hunterlea91
Co-authors:
Ahmed7
Rationale for change
NN video platelet disorders: https://youtu.be/i_c8x7TiHN0?si=sgt6pHdaCyiYjgxq
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Text
What hematologic laboratory values are consistent with abnormal hemostasis due to chronic kidney disease?
PT: {{c1::Normal}}
PTT: {{c1::Normal}}
Platelet count: {{c1::Normal}}
Bleeding time: {{c1::Prolonged}}
Extra
- Underlying cause is platelet dysfunction

Proposed mechanism
- ↑ urea → arginine shunted to guanidinosuccinic acid (GSA), precursor to nitric oxide
- ↑ nitric oxide → ↓ vWF secretion by endothelial cells → ↓ platelet adhesion
- ↑ nitric oxide → ↓ ADP and TXA2 / ↓ activation of GplIb/Illa receptor → ↓ platelet activation and aggregation

Lecture Notes
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Pathoma
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Boards and Beyond
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First Aid
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Sketchy 2



Watch Chronic Kidney Disease (CKD): Complications & Management






Watch Acute Upper GI Bleed: Non-Variceal Bleeding







Watch Bleeding Disorders: Platelet Disorders DDx




Watch Bleeding Disorders: Coagulation Factor Disorders DDx



Watch Chronic Kidney Disease (CKD): Complications & Management






Watch Acute Upper GI Bleed: Non-Variceal Bleeding







Watch Bleeding Disorders: Platelet Disorders DDx




Watch Bleeding Disorders: Coagulation Factor Disorders DDx
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