Created at 11:42 a.m. Jan, 04, 2026
Author: nojmi
Related Note: 1487117300306 4
Rationale for change

The current text implies that Fas binding causes TNF release, which is incorrect. While FasL belongs to the TNF superfamily, the pathway works by direct recruitment of FADD and activation of caspase-8, independent of TNF release. The attached image also correctly shows parallel pathways (Perforin/Granzyme and Fas/FasL), not a sequential TNF release.

Sources: First Aid 2025 (p. 204), Amboss (Apoptosis: Extrinsic pathway). https://next.amboss.com/us/article/VP0GdT?q=Fas%20ligand#Ya96855d22400d5c0ea51fda9bfa76750

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