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at 7:30 p.m. Jan, 03, 2026
by
Ahmed7
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Rationale for change
NBME 28 Question 24
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Text
{{c1::Astrocytes}} are glial cells that are capable of removing excess neurotransmitters
Extra
- Reuptake and metabolize glutamate and GABA
- Astrocytes use NH3 and glutamate to make glutamine (which is then shuttled to neurons who convert it back to glutamate for neurotransmission)
- In hyperammonemia, astrocytes get fed too much NH3, and thus they make too much glutamine which causes the astrocytes to swell and become dysfunctional (depleting glutamate stores)
- Thus GABA is not metabolized and there is an excess of GABA in the CNS (energy supply to other brain cells is decreased)
- This results in impaired excitatory neurotransmitter release
Lecture Notes
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Pathoma
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Boards and Beyond
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First Aid




Sketchy
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Sketchy 2
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Picmonic
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Pixorize
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Physeo
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OME
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