Accepted
at 7:17 p.m. Dec, 16, 2025
by
jaynguyen
Author:
jdeng95
Type of change:
Updated content
Rationale for change
Better clozes that don't give away the answer
Before
After
Text
Text
Text
Text
Extra
Also occurs due to mutations in the TGM1, NIPAL4 (ICHTHYIN) and PNPLA1 genes
Personal Notes
Empty field
Missed Questions
Empty field
DermPath
Empty field
Dermoscopy
Empty field
VisualDx
Empty field
DermNet
Empty field
Full Spectrum of Dermatology
Empty field
Dermnemonics
Red Snapper: Congenital Icthyosiform Erythroderma
Aloe Bottle with Heart (3) for an O: ALOXE3
Sword (1) and Eel (Swan of the sea) (2): ALOX12B
Aloe Bottle with Heart (3) for an O: ALOXE3
Sword (1) and Eel (Swan of the sea) (2): ALOX12B
Dermatographix
ALOE for Ages 3-12: Mutations in ALOXE3 and ALOX12B most commonly implicated in CIE
Congenital Ichthyosiform Erythroderma (CIE)
Congenital Ichthyosiform Erythroderma (CIE)
- Sunburned baby fish = Congenital ichthyosiform erythroderma
- Rubbing aloe on sunburn = ALOXE3 and ALOX12B mutations
- Ages 3-12 = Reinforces E3 and 12B above
- Red fish inside collodion bubble = Presents with collodion membrane at birth
- Fine white popped bubbles around it = After collodion resolves, fine white scale in generalized distribution
- Elbow pad = Flexures are involved
- Queen fish riding a Harley = Harlequin ichthyosis
- Goggles = Extreme ectropion
- Wind resistance blowing her lips = Eclabium
- Headphones = Ear deformities
- ABC 123 = ABCA12 mutation
- Retinoid asteroid = Early initiation of systemic retinoids and specialized NICU care reduces mortality
- Dead fish = Neonatal death often occurs
- Fish on fire = Death may be due to sepsis
- Baby diver unable to breathe due to broken oxygen tank = Death may be due to respiratory insufficiency
- Bull-fish = Epidermolytic ichthyosis (bullous CIE)
- Pulling a cart = KRT mutations
- Back wheel propped up with a 1-shaped jack = KRT1 mutation
- 1-shaped jack creates bumps in the sand because it can’t roll = Associated with palmoplantar keratosis (PPK)
- O-shaped front wheel rides smoothly = No significant PPK
- Red baby fish blowing bubbles = Presents at birth with erythroderma and blistering
- Adult fish with cobblestone scale pattern = Later in life presents with hyperkeratosis with cobblestone pattern, most prominent over the joints
- Retinoid asteroid causing cobblestones to break = Retinoids can exacerbate skin fragility
- Smelly bullpoop = Frequent skin infections and malodor
Textbook
Empty field
Additional Resources
Empty field
One by one
Empty field