This card is quite poorly worded. The result of chronic kidney disease is a decrease in the production of 1,25-dihydroxycholecalciferol by means of having ineffective 1a-hydroxylase hydroxylation.
Vitamin D resistance would instead refer to a situation where vitamin D was present at normal/physiologic levels but not responded to (i.e., Vitamin D receptor mutation).
As per AMBOSS, vitamin D resistance is seen in conditions such as Vitamin D-dependent Ricket's type 2 which they describe it as "An autosomal recessive mutation in the vitamin D receptor gene causes end-organ resistance to vitamin D"
AMBOSS URL: [https://next.amboss.com/us/article/XT0962?q=Vitamin%20D%20resistance#Z33d906b290fa74efdb43529191dc3dec]
I have changed the wording of this card to better reflect the concept being tested here, which is that CKD commonly results in a deficiency of activated Vitamin D.
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