Accepted at 11:27 a.m. Nov, 28, 2025 by Cameron
Author: zarathustra
Related Note: 1482886861200
Rationale for change

- The current note conflates Prokaryotic repair (where methylation = strand discrimination) with Human pathology (where methylation = gene silencing)

- Humans rely on nicks and PCNA for strand ID, not methylation (Source: https://pubmed.ncbi.nlm.nih.gov/16612326/)

- Sporadic MSI: Caused by MLH1 promoter hypermethylation → transcriptional silencing (Source: https://www.amboss.com/us/knowledge/colorectal-cancer)

- Lynch Syndrome: Caused by germline mutations, distinct from epigenetic silencing (Source: https://www.amboss.com/us/knowledge/lynch-syndrome)

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