Accepted at 11:27 a.m. Nov, 28, 2025 by Cameron
Author: zarathustra
Related Note: 1482886861200
Rationale for change

- The current note conflates Prokaryotic repair (where methylation = strand discrimination) with Human pathology (where methylation = gene silencing)

- Humans rely on nicks and PCNA for strand ID, not methylation (Source: https://pubmed.ncbi.nlm.nih.gov/16612326/)

- Sporadic MSI: Caused by MLH1 promoter hypermethylation → transcriptional silencing (Source: https://www.amboss.com/us/knowledge/colorectal-cancer)

- Lynch Syndrome: Caused by germline mutations, distinct from epigenetic silencing (Source: https://www.amboss.com/us/knowledge/lynch-syndrome)

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#AK_Step1_v12::#SketchyPath::05_GI::03_Colorectal_&_Anal_Disorders::03_Colorectal_Polyps_&_Cancer #AK_Step2_v12::#B&B::06_GI::04_Intestines::01_Colon_Cancer::Extra #AK_Step1_v12::^Systems::GI::pathology #AK_Step1_v12::#Physeo::11_Pathology::07_General_Pathology::09_Carcinogenesis #AK_Step1_v12::#Pathoma::10_GI::08_Colon #AK_Other::AnKing_Image::Marcos::Colonic_polyps #AK_Other::Only_Step_1 #AK_Step1_v12::#OME::Clinical::04_Organ_Systems::03_Gastrointestinal::01_Digestion_&_Absorption::12_Neoplasia_of_Large_Intestine #AK_Other::^EXPN::BGedit #AK_Step1_v12::#FirstAid::09_Gastrointestinal::04_Pathology::26_Colonic_polyps::*Neoplastic::Serrated #AK_Other::#AK_Original_Decks::Step_1::Zanki_Step_Decks::Zanki_GI::GI_Pathology #AK_Step1_v12::#Bootcamp::Gastroenterology::09_Large_Intestine::14_Colorectal_Carcinogenesis_Molecular_Pathway #AK_Step1_v12::#OME::04_Organ_Systems::03_Gastrointestinal::01_Digestion_&_Absorption::12_Neoplasia_of_Large_Intestine #AK_Step1_v12::#Low/HighYield::3-HighYield-temporary #AK_Other::AnKing_Image::!Subjects::Gastroenterology::Colonic_polyps