Bulk Suggestion
Bulk ID:
alexlewis/07.15.24-12:52AM
Accepted at: Aug, 13, 2024
4:47 a.m.
Author:
alexlewis
Related Deck:
1675118865074
Accepted
Rationale for new note
Spinal cord syndromes
Text
What is the mechanism of action of Ethosuximide?
{{c1::Inhibits T-type Ca2+ channels in thalamocortical neurons which are generators of 3 Hz spike-and-wave discharges}}
{{c1::Inhibits T-type Ca2+ channels in thalamocortical neurons which are generators of 3 Hz spike-and-wave discharges}}
Text
What is the <u>mechanism of action</u> of <b>Ethosuximide</b>?
<br><br>{{c1::Inhibits <span style="">T-type Ca<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: initial; top: -0.5em;">2+</span> channels</span> in <span style="">thalamocortical neurons</span> which are generators of 3 Hz spike-and-wave discharges}}
Extra
-Thalamocortical neurons are hypothesised to be generators of the classic 3 Hz spike-and-wave discharges seen with absence seizures and rely heavily on low threshold T-type calcium channels to do so.
-Ethosuximide can lower the threshold of T-type calcium currents and disrupt the oscillatory activity of thalamocortical circuitry by blocking T-type calcium channels
-Ethosuximide can lower the threshold of T-type calcium currents and disrupt the oscillatory activity of thalamocortical circuitry by blocking T-type calcium channels
Extra
-Thalamocortical neurons are hypothesised to be generators of the classic 3 Hz spike-and-wave discharges seen with absence seizures and rely heavily on low threshold T-type calcium channels to do so.<br>-Ethosuximide can lower the threshold of T-type calcium currents and disrupt the oscillatory activity of thalamocortical circuitry by blocking T-type calcium channels
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Oxford Handbook
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eTG Complete
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Source
StatPearls Accessed 23 July 2024
Source
<a href="https://www.ncbi.nlm.nih.gov/books/NBK544244/#_article-21395_s3_">StatPearls</a> Accessed 23 July 2024
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#Malleus_CM::#Resources_by_Rotation::Internal_Medicine::Neurology
#Malleus_CM::#Subjects::Neurology_&_Ophthalmology::09_Seizure::10_Management
#Malleus_CM::#Subjects::Pharmacology::07_Neuro/Psych::04_Mood_Stabilisers_&_Antiepileptic_Drugs::Ethosuximide::02_Mechanism_of_Action