Bulk Suggestion
Bulk ID:
alexlewis/07.15.24-12:52AM
Accepted at: Aug, 13, 2024
4:54 a.m.
Author:
alexlewis
Related Deck:
1675118865074
Accepted
Rationale for new note
Spinal cord syndromes
Text
What is the mechanism of action of sodium valproate?
{{c1::Reduces neuronal excitability by indirectly inhibiting GABA transaminase}}
{{c1::Reduces neuronal excitability by indirectly inhibiting GABA transaminase}}
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What is the <u>mechanism of action</u><i> </i>of <b>sodium valproate</b>?<br><br>{{c1::Reduces neuronal excitability by indirectly inhibiting GABA transaminase}}<br>
Extra
- Directly inhibits semialdehyde dehydrogenase, causing increased succinct semialdehyde which itself inhibits GABA transaminase
- Also inhibits T-type Ca2+ channels and voltage-gated Na+ channels
- Overall leads to attenuation of high-frequency neuronal firing
- Also inhibits T-type Ca2+ channels and voltage-gated Na+ channels
- Overall leads to attenuation of high-frequency neuronal firing
Extra
- Directly inhibits semialdehyde dehydrogenase, causing increased succinct semialdehyde which itself inhibits GABA transaminase<br>- Also inhibits <span style="">T-type</span> <span style="">Ca<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: initial; top: -0.5em;">2+</span></span> channels and <span style="">voltage-gated Na<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: initial; top: -0.5em;">+</span> channels</span><br>- Overall leads to attenuation of high-frequency neuronal firing
Extra (Synced)
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Extra (Synced)
Personal Notes
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Missed Questions
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Missed Questions
eTG Complete
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eTG Complete
Talley & O'Connor
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Talley & O'Connor
Additional Resources
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Additional Resources
Additional Resources (Synced)
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Additional Resources (Synced)
Source
AMBOSS Accessed 23 July 2024
StatPearls Accessed 23 July 2024
StatPearls Accessed 23 July 2024
Source
<a href="https://next.amboss.com/us/article/-N0Ddg#Zfe47f4f5fb7f8de32f7919dc8909896e">AMBOSS</a> Accessed 23 July 2024<br><a href="https://www.ncbi.nlm.nih.gov/books/NBK559112/#_article-30956_s3_">StatPearls</a> Accessed 23 July 2024
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Tags
#Malleus_CM::#Resources_by_Rotation::General_Practice
#Malleus_CM::#Resources_by_Rotation::Internal_Medicine::Neurology
#Malleus_CM::#Subjects::Neurology_&_Ophthalmology::09_Seizure::10_Management
#Malleus_CM::#Subjects::Pharmacology::07_Neuro/Psych::04_Mood_Stabilisers_&_Antiepileptic_Drugs::Valproate::02_Mechanism_of_Action