Bulk Suggestion
Bulk ID:
alexlewis/07.15.24-12:52AM
Accepted at: Aug, 13, 2024
4:54 a.m.
Author:
alexlewis
Related Deck:
1675118865074
Accepted
Rationale for new note
Spinal cord syndromes
Text
What is the mechanism of action of sodium valproate?
{{c1::Reduces neuronal excitability by indirectly inhibiting GABA transaminase}}
{{c1::Reduces neuronal excitability by indirectly inhibiting GABA transaminase}}
Text
What is the <u>mechanism of action</u><i> </i>of <b>sodium valproate</b>?<br><br>{{c1::Reduces neuronal excitability by indirectly inhibiting GABA transaminase}}<br>
Extra
- Directly inhibits semialdehyde dehydrogenase, causing increased succinct semialdehyde which itself inhibits GABA transaminase
- Also inhibits T-type Ca2+ channels and voltage-gated Na+ channels
- Overall leads to attenuation of high-frequency neuronal firing
- Also inhibits T-type Ca2+ channels and voltage-gated Na+ channels
- Overall leads to attenuation of high-frequency neuronal firing
Extra
- Directly inhibits semialdehyde dehydrogenase, causing increased succinct semialdehyde which itself inhibits GABA transaminase<br>- Also inhibits <span style="">T-type</span> <span style="">Ca<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: initial; top: -0.5em;">2+</span></span> channels and <span style="">voltage-gated Na<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: initial; top: -0.5em;">+</span> channels</span><br>- Overall leads to attenuation of high-frequency neuronal firing
Personal Notes
Empty field
Personal Notes
Missed Questions
Empty field
Missed Questions
Oxford Handbook
Empty field
Oxford Handbook
First Aid
Empty field
First Aid
AMBOSS
Empty field
AMBOSS
eTG Complete
Empty field
eTG Complete
Talley & O'Connor
Empty field
Talley & O'Connor
Additional Resources
Empty field
Additional Resources
Source
Source
<a href="https://next.amboss.com/us/article/-N0Ddg#Zfe47f4f5fb7f8de32f7919dc8909896e">AMBOSS</a> Accessed 23 July 2024<br><a href="https://www.ncbi.nlm.nih.gov/books/NBK559112/#_article-30956_s3_">StatPearls</a> Accessed 23 July 2024
One by one
Empty field
One by one
Tags
#Malleus_CM::#Resources_by_Rotation::General_Practice
#Malleus_CM::#Resources_by_Rotation::Internal_Medicine::Neurology
#Malleus_CM::#Subjects::Neurology_&_Ophthalmology::09_Seizure::10_Management
#Malleus_CM::#Subjects::Pharmacology::07_Neuro/Psych::04_Mood_Stabilisers_&_Antiepileptic_Drugs::Valproate::02_Mechanism_of_Action