Created at 3:48 a.m. Nov, 19, 2025
Author: rakirs1
Related Note: 1478834583723 1
Rationale for change

While alpha tetramers can form, the principle cause for extravascular hemolysis and ineffective erythropoiesis is due to the unpaired alpha chains precipitating together. These are still in a monomeric form, just clumped up togther.

"Unpaired α chains precipitate and damage RBC membrane, resulting in ineffective erythropoiesis and extravascular hemolysis (removal of circulating RBCs by the spleen)." - Pathoma

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