Created at 10:35 p.m. Nov, 06, 2025
Author:
t.aylor.wilson
Type of change:
Updated content
Rationale for change
needs to be more specific. Does not assist in the creation of tropocollagen, which is also a triple helical structure in the collagen synthesis pathway
Source: Other - FA2025p48
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- In osteogenesis imperfecta; deficient type 1 collagen replaces glycine with a bulky amino acid, creating steric hindrance that prevents 3 pro-alpha chains from properly linking into the triple helix procollagen; This improper collagen structure is either destroyed in the fibroblast, or is faultily incorporated into bone with hydroxyapatite causing brittleness
- In scurvy, these patients can't hydroxylate pro-alpha chains (hydroxylation of proline or lysine requires vit C), thus they can't form the triple helix and the nascent collagen is degraded in the cell without being secreted

Lecture Notes
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Missed Questions
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Pathoma
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Boards and Beyond
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First Aid




Sketchy 2
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Sketchy Extra
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Picmonic
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Physeo
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Bootcamp
Watch associated Bootcamp video - Connective Tissue: Collagen Synthesis
Watch associated Bootcamp video - Connective Tissue: Osteogenesis Imperfecta
Watch associated Bootcamp video - Connective Tissue: Osteogenesis Imperfecta
OME
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