Created at 2:46 a.m. Oct, 31, 2025
Author:
irksomefire
Type of change:
Content error
Rationale for change
SERMs are not considered as chemotherapeutic drugs. I believe that it's better to either re-phrase or delete the word altogether.
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- Tamoxifen has anti-estrogenic effects on the breast but weak pro-estrogenic effects on the endometrium and bone
- Thus risk of endometrial cancer

- Thus risk of endometrial cancer
| Selective Estrogen Receptor Modulators (SERMs) | Breast | Uterus | Bone |
|---|---|---|---|
| Tamoxifen | - | + | + |
| Raloxifene | - | - | + |
| Clomiphene | - (in hypothalamus) | ||
| ER agonist = +; ER antagonist = - | |||


Photo credit: © Dr. Jian-Hua Qiao, all rights reserved, via Flickr (used with permission)
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Watch associated Bootcamp video - Pharmacology: Selective Estrogen Receptor Modulators
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