Created at 12:37 a.m. Sep, 20, 2025
Author:
yelbardisi
Co-authors:
andrewmathias8
Type of change:
Updated content
Rationale for change
Only open NTDs have elevated AFP and AchE (closed NTDs have normal AFP levels)
Important to clarify this
Source: AMBOSS - https://next.amboss.com/us/article/el0xDT?utm_source=navbar&utm_medium=anki&utm_campaign=anki&utm_term=neural%2Btube%2Bdefects&guid=zz%253F9Xcxv%2525O&aid=79f7d232-7b36-4395-b059-e1ee1e13b104&uid=ehl1x19S0#Z055c25fa28c4eb8c6bb0672e557eef80
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- Initial screening test at 16-18 weeks looks for increased maternal serum AFP
- Fetal AChE/AFP in CSF flows through defect into amniotic fluid
- Fetal AChE/AFP in CSF flows through defect into amniotic fluid
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