Just look at the chart.
Postganglionic sympathetic neurons primarily release norepinephrine, which acts on α1, α2, β1, and (to a lesser extent) β2 receptors. Epinephrine is secreted mainly from the adrenal medulla and reaches adrenergic receptors via the bloodstream as a hormone, not as a postganglionic neurotransmitter. So this card is misleading as written.
You could say:
Post-ganglionic sympathetic neurons may utilize {{c1::norepinephrine}} as a neurotransmitter, which binds to α1, α2, β1 receptors. (And then indicate in the extra field: Norepinephrine can bind to β2 receptors, but its affinity is very low, so the effect is usually negligible physiologically.)
Or you could say:
{{c1::Epinephrine}} is secreted by the adrenal medulla into the bloodstream and acts as a hormone, binding to adrenergic receptors (α1, α2, β1, and β2).
• McCorry, L. K. (2007). Physiology of the autonomic nervous system. AJPE, 71(4), 78.
• Adams, H. R. (2001). Veterinary Pharmacology and Therapeutics. Wiley.
• Westfall, T. C., & Westfall, D. P. (2011). Goodman & Gilman’s The Pharmacological Basis of Therapeutics. McGraw-Hill.
• Katzung, B. G. (2009). Basic & Clinical Pharmacology. McGraw-Hill.
• Hein, L. (2006). Adrenoceptors and signal transduction in neurons. Cell and Tissue Research, 326(2), 541–551.
• Ebert, T. J. (2013). Autonomic nervous system pharmacology. Elsevier.
• Vivas, O., Tuthill, J., & Hille, B. (2023). Autonomic nervous system physiology. UW Pressbooks.
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