Created at 5:45 p.m. Aug, 19, 2025
Author:
arvinddraffen
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Question on FM NBME Form 3 on this topic
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Primary hyperaldosteronism activates "aldosterone escape", which leads to a steady state of {{c1::normonatremia::sodium levels}}, {{c1::hypokalemia::potassium levels}} and {{c1::hypervolemia::volume levels}}
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- Excess aldosterone → increased Na+ reabsorption → negative luminal charge, which pulls K+ and H+ into urine → hypokalemia + metabolic alkalosis
- Despite the increase in Na+ reabsorption, hypernatremia and pedal edema are rarely observed due to increased intravascular volume, which increases renal blood flow (resulting in pressure natriuresis and normal sodium levels)


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