Created at 1:10 a.m. Aug, 10, 2025
Author: uchihamarek
Related Note: 1487461053514 3
Rationale for change

1. Robbins Basic Pathology, 10th ed., Ch. 7 “Neoplasia”
• Describes the PI3K–AKT–mTOR pathway in growth signalling:
“AKT phosphorylates and inactivates the TSC1–TSC2 complex, relieving its inhibition of Rheb, which activates mTOR.”
This directly links AKT activity to mTOR activation.

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