Created at 4:26 p.m. Aug, 09, 2025
Author:
catherinemiller
Rationale for change
The table shows decreased β-hCG in the 1st trimester for both Patau and Edwards. But in the 2nd trimester, only Edwards is decreased. So either the card or the table is wrong, or at least not properly specified.
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Edwards syndrome and Patau syndrome are also characterized by a decreased PAPP-A

| Trisomy | Patau (13) | Edward (18) | Down (21) |
|---|---|---|---|
| First Trimester | |||
| β-hCG | ↓ | ↓ | ↑ |
| PAPP-A | ↓ | ↓ | ↓ |
| Second Trimester | |||
| β-hCG | ↔ | ↓ | ↑ |
| Inhibin A | ↔ | ↔ or ↓ | ↑ |
| α-fetoprotein (AFP) | ↔ | ↓ | ↓ |
| Estriol | ↔ | ↓ | ↓ |

Lecture Notes
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Missed Questions
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Pathoma
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Boards and Beyond
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First Aid




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Watch Edwards & Patau Syndromes



Watch Edwards & Patau Syndromes
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Bootcamp
Watch associated Bootcamp video - High Yield Genetic Disorders : Autosomal Trisomies
Watch associated Bootcamp video - Pregnancy and Menstruation : Hormones of Pregnancy
Watch associated Bootcamp video - Pregnancy and Menstruation : Hormones of Pregnancy
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Additional Resources
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