Accepted
at 2:24 p.m. Aug, 08, 2025
by
Brian_BH
Author:
marigold_lung
Type of change:
Spelling/Grammar
Rationale for change
consistency
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- ACh is released from axon terminal of motor neuron and binds to receptors on the motor end plate
- Binding of ACh to motor end plate receptors elicits triggers an action potential in the muscle cell
- The action potential travels along the sarcolemma and down the T tubules
- The action potential activates voltage-gated L-type calcium channels in the plasma membrane
- The inflow of calcium through the L-type calcium channels activates ryanodine receptors to release calcium ions from the sarcoplasmic reticulum down it's concentration gradient into the cytosol of muscle cells, which then allows for initiation of muscle contraction
- The sarcoplasmic reticulum Ca2+-ATPase (SERCA) then pumps calcium back into the sarcoplasmic reticulum after contraction to restore the calcium concentration gradient and allow for a new contraction
Photo credit: Essau Mejia, CC BY-SA 4.0, via Wikimedia Commons
Photo credit: Colorado Community College System Anatomy and Physiology via Pressbooks CC 4.0
Sarcoplasmic Reticulum (Khan Academy)
Photo credit: Daniel Walsh and Alan Sved, CC BY-SA 4.0, via Wikimedia Commons
Calcium Regulation of Contraction - Jack Westin
- Binding of ACh to motor end plate receptors elicits triggers an action potential in the muscle cell
- The action potential travels along the sarcolemma and down the T tubules
- The action potential activates voltage-gated L-type calcium channels in the plasma membrane
- The inflow of calcium through the L-type calcium channels activates ryanodine receptors to release calcium ions from the sarcoplasmic reticulum down it's concentration gradient into the cytosol of muscle cells, which then allows for initiation of muscle contraction
- The sarcoplasmic reticulum Ca2+-ATPase (SERCA) then pumps calcium back into the sarcoplasmic reticulum after contraction to restore the calcium concentration gradient and allow for a new contraction
Photo credit: Essau Mejia, CC BY-SA 4.0, via Wikimedia Commons
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Photo credit: Colorado Community College System Anatomy and Physiology via Pressbooks CC 4.0
Sarcoplasmic Reticulum (Khan Academy)
Photo credit: Daniel Walsh and Alan Sved, CC BY-SA 4.0, via Wikimedia Commons
Calcium Regulation of Contraction - Jack Westin
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