Accepted
at 7:08 p.m. Jul, 30, 2025
by
heptachlor
Author:
pock
Type of change:
Spelling/Grammar
Rationale for change
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Suffix: First generation antipsychotics
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"-azine"
(Don't confuse the "-zine" of H1 receptor blockers with the "-azine" of typical antipsychotics)
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Name a first generation antispsychotic without the suffix "-zine"
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Haloperidol
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MOA: First generation antipsychotics
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Inhibit central D2 receptors
(Its primary mechanism of action)
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What are the high potency first generation antipsychotics?
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(1) Trifluoperazine/Fluphenazine
(2) Haloperidol
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What are the low potency first generation antipsychotics?
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(1) Thioridazine
(2) Chlorpromazine
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Indications (4) : First generation antipsychotics
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(1) Schizophrenia
(2) Acute psychosis
(3) Acute aggresion/agitation
(4) Tourette's syndrome
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Do first generation antipsychotics have a short or long half-life?
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Long
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Other than D2 receptors, what receptors do first generation antipsychotics inhibit?
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(1) Muscarinic receptors
(2) α1 receptors
(3) H1 receptors
(Note: this occurs predominantly in the LOW potency first generation antipsychotics)
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What type of side effects are more common in first generation antipsychotics compared to second generation?
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Extra pyramidal symptoms
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What type of extra pyramidal symptoms can occur within minutes of starting a high potency first generation antipsychotics?
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Acute dystonia
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What type of extra pyramidal symptoms can occur within days of starting a high potency first generation antipsychotics?
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Akathisia
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What type of extra pyramidal symptoms can occur within weeks of starting a high potency first generation antipsychotics?
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(1) Drug-induced Parkinson
(2) Tardive dyskinesia
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Name 2 endocrine abnormalities that can occur secondary to high potency first generation antipsychotic use
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(1) ↓ Dopamine ⇒ ↑ Prolactin
(2) ↑ Prolactin ⇒ ↓ GnRH
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Adverse Effects - Non-endocrine (3) : Typical antipsychotics
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(1) Neuroleptic malignant syndrome
(2) Torsades de pointes
(3) Seizures
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What are the symptoms of neuroleptic malignant syndrome?
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(1) Lead-pipe rigidity
(2) Autonomic instability
(3) Rhabdomyolysis
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Retinal deposits
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What is a distinctive side effect of Chlorpromazine?
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Yellow corneal deposits
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Do first generation antipsychotics better treat positive or negative symptoms of schizophrenia?
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Positive
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More About This Topic
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5.1 - First generation antipsychotics 
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