Accepted
at 1:44 p.m. Jul, 15, 2025
by
Brian_BH
Author:
jbhullar
Type of change:
Other
Rationale for change
Pathway, could be 1by1
Before
After
One by one
One by one
One by one
One by one
Text
The translation and processing of secretory proteins starts in the cytosol and then proceeds as follows:
cytosol → {{c1::rough endoplasmic reticulum}} → {{c1::golgi apparatus}} → {{c1::secretory vesicles}} → {{c1::plasma membrane}}
cytosol → {{c1::rough endoplasmic reticulum}} → {{c1::golgi apparatus}} → {{c1::secretory vesicles}} → {{c1::plasma membrane}}
Extra
- Translation of mRNA to proteins begins in the cytosol. From there, proteins meant for cellular use travel to their intracellular destination.
- However, proteins intended for the secretory pathway have N-terminal signal sequences that causes them to be transferred to the rough endoplasmic reticulum (RER)
- In the RER, post-translational modifications such as glycosylation, disulfide bond formation, phosphorylation, and protein cleavage can occur.
- The RER then packages proteins into vesicles and sends them to the golgi aparatus for further processing (retrograde processing)
- Finally, the golgi apparatus packages proteins into secretory vesicles which fuse with the plasma membrane and releases the contents outside of the cell
Photo credit: Giovanna De Chiara, Maria Elena Marcocci, Rossella Sgarbanti, Livia Civitelli, Cristian Ripoli, Roberto Piacentini, Enrico Garaci, Claudio Grassi, Anna Teresa Palamara, CC BY 2.5, via Wikimedia Commons
Golgi apparatus: general structure and role in packaging and secretion - Jack Westin
- However, proteins intended for the secretory pathway have N-terminal signal sequences that causes them to be transferred to the rough endoplasmic reticulum (RER)
- In the RER, post-translational modifications such as glycosylation, disulfide bond formation, phosphorylation, and protein cleavage can occur.
- The RER then packages proteins into vesicles and sends them to the golgi aparatus for further processing (retrograde processing)
- Finally, the golgi apparatus packages proteins into secretory vesicles which fuse with the plasma membrane and releases the contents outside of the cell
Photo credit: Giovanna De Chiara, Maria Elena Marcocci, Rossella Sgarbanti, Livia Civitelli, Cristian Ripoli, Roberto Piacentini, Enrico Garaci, Claudio Grassi, Anna Teresa Palamara, CC BY 2.5, via Wikimedia Commons
Golgi apparatus: general structure and role in packaging and secretion - Jack Westin
Lecture Notes
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Missed Questions
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Additional Resources
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