Accepted at 7:58 p.m. Oct, 31, 2023 by Alex
Author: harmorgmed
Related Note: 1487642936903
Rationale for change

Wrong description


Quote from Robbin's pathology with citation


In the usual H&E stained tissue samples (Fig. 3.22), the activated macrophages in granulomas have pink granular cytoplasm with indistinct cell boundaries and are called epithelioid cells. A collar of lymphocytes surrounds the aggregates of epithelioid macrophages. Older granulomas may have a rim of fibroblasts and connective tissue. Frequently, but not invariably, multinucleated giant cells 40 to 50 µm in diameter are found in granulomas; these are called Langhans giant cells. They consist of a large mass of cytoplasm and many nuclei.

Kumar, Vinay; Abbas, Abul K.; Aster, Jon C.. Robbins Basic Pathology E-Book (Robbins Pathology) (p. 85). Elsevier Health Sciences. Kindle Edition.

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Extra
The defining feature of a granuloma is the epithelioid histiocyte (macrophage with pink cytoplasm)

 


Photo credit: Ed Uthman, MDCC BY-SA 2.0, via Wikimedia Commons; the supplementary image with overlays of the relevant areas was adapted from the image mentioned previously, licensed under CC BY-SA 2.0Sanjay Mukhopadhyay, Public domain, via Wikimedia Commons
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